The 27-year-old defender has been charged with four counts of rape and one count of sexual assault, Cheshire Police said.
The charges relate to three complainants over the age of 16,
and are alleged to have taken place between October 2020 and August this year.
Mr Mendy, of Prestbury, has been remanded in custody and will appear at Chester Magistrates’ Court on Friday.
The left-back has played for last season’s Premier League champions since 2017,
when he joined from Monaco for a reported £52m.
A police spokesman said: “Cheshire Constabulary and the Crown Prosecution Service would like to remind everyone,
that criminal proceedings against Mendy are live and that he has a right to a fair trial.”
Manchester City said the defender, who also plays for the French national team, had been suspended pending an investigation.
“The matter is subject to a legal process and the club is therefore unable to make further comment until that process is complete,” the club added.