Liverpool will be without Arthur, Luis Diaz, Diogo Jota, Roberto Firmino and Virgil van Dijk, but Klopp is expecting Darwin Nunez to bounce back to first eleven.
Nunez’s return should see Cody Gakpo revert to a wide role as Fabio Carvalho makes way, while Kostas Tsimikas suffered a knock to the back at Molineux but was always expected to cede his place to Andrew Robertson.
Klopp has previous in throwing young players in against Chelsea, starting Harvey Elliott against the Blues at Anfield last season.
Elliott scored the winner against Wolves and could start once again, while impressive young midfielder Stefan Bajcetic is pushing to replace either Fabinho or Thiago in the engine room.
Chelsea new boy Mudryk will be in contention to make his Blues debut, and he could potentially replace Felix.
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Reece James and Ben Chilwell have both re-joined their Blues teammates in training this week, although neither will play any part on Merseyside.
Ruben Loftus-Cheek was an unused substitute in Chelsea’s 1-0 win over Crystal Palace on Sunday, returning after a two-month absence with an ankle problem.
That leaves Raheem Sterling, Christian Pulisic, N’Golo Kante, Wesley Fofana, Edouard Mendy, Denis Zakaria and Armando Broja still on the sidelines.
Noni Madueke, the £29m signing from PSV Eindhoven, has also joined but wasn’t registered in time to face Liverpool.
Predicted Liverpool XI:
Alexander-Arnold, Konate, Gomez, Robertson;
Bajcetic, Thiago, Elliott;
Salah, Nunez, Gakpo
Predicted Chelsea XI:
Chalobah, Thiago Silva, Badiashile, Hall;
Gallagher, Kovacic, Ziyech;
Mount, Havertz, Mudryk