Manchester United will be without the services of Axel Tuanzebe due to a long-term issue, while Jadon Sancho remains a major doubt due to his ongoing fitness problems.
Donny van de Beek will also be missing due to the serious injury that he picked up against Bournemouth.
Anthony Martial should be available despite suffering a knock in Tuesday’s fixture with the Cherries.
Antony is also a major doubt due to the problem that forced him to miss the team’s last game.
Donny van de Beek is definitely sidelined after suffering what appeared to be a serious injury against the Cherries, though both Lisandro Martinez and Diogo Dalot are pushing to start the cup game.
Jack Butland is set to join on loan from Crystal Palace, though it remains to be seen if he will be registered in time to feature.
Predicted Manchester United XI:
Dalot, Varane, Martinez, Shaw;
Garnacho, Fernandes, Rashford;