The likely absence of Dejan Kulusesvki with a hamstring strain is a blow for Tottenham but has spared Antonio Conte a difficult decision over his front three for the crunch clash with Arsenal.
Heung-min Son, who scored a stunning hat-trick from the bench against Leicester last time out, will replace the Swede, likely forming an attacking along with Richarlison and Harry Kane.
Conte has not ruled out a switch to 3-5-2 but he has favoured a 3-4-3 system.
Ben Davies suffered a knock to his knee in the Champions League defeat to Sporting Lisbon and missed Wales’ internationals, so Clement Lenglet is expected to start on the left of the back three.
Conte has hinted at more opportunities for his summer signings – as well as Matt Doherty and Oliver Skipp – after the international break,
but given the magnitude of the game, the head coach is likely to stick with Emerson Royal at right wing-back, and a midfield two of Pierre-Emile Hojbjerg and Rodrigo Bentancur.
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Speaking of Skipp, Conte said: ““For Skippy, it was important [to play for the England U21s].
“But for me it was the same for Matthew [Doherty], for [Djed] Spence to play games and,
for sure, Skippy played his last game in January and has been suffering a bit to find again his physical condition,
but we are talking about a really good guy with a great desire, great will and it was important for him to play one game and then 20 minutes in the second game.
The only other question for the Spurs head coach is whether to play Ivan Perisic or Ryan Sessegnon at left wing-back, or even move Perisic to the right, as he did against Leicester.
The experienced Croatian can expect to get the nod on his preferred side, not least because he is such a threat at delivering set-pieces.
Conte confirmed some players had returned from international duty with “physical problems” but pushed for more details, he said:
“Honestly I don’t want to speak about the injury because I don’t want to give advantage to Arsenal.
“But for sure we have to face some problems, some physical problems and we have to know also that we have just started to play the first game in a run that we have to play 13 days in 43 days.
“For sure we have to try to make the best solution and to try not to take big risks because if we take big risks and lose players for the rest of the games, it will be a disaster.
I repeat to play every three days I need to count on the whole squad and we try with the players to also make the best decision.”
Spurs predicted XI (3-4-3):
Romero, Dier, Lenglet;
Emerson, Hojbjerg, Bentancur, Perisic;
Richarlison, Son, Kane.