Arsenal could hand debuts to both Oleksandr Zinchenko and Fabio Vieira as they face Chelsea in an all-London pre-season friendly in Orlando.
Zinchenko trained with his team-mates on Friday and could also get a short run out just a day after joining the club.
Nuno Tavares has been linked with a loan exit, but could feature.
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Vieira is yet to get his first minutes in a Gunners shirt under his belt after picking up a small foot injury shortly after his arrival.
The 22-year-old has been participating in training and will be assessed ahead of kick-off.
Three players who will not be involved are Emile Smith Rowe, Takehiro Tomiyasu and Kieran Tierney, who have all been absent from training.
Mikel Arteta should name a strong starting line-up, with the new Premier League season starting in less than two weeks,
so the likes of Bukayo Saka, Martin Odegaard, William Saliba, Ben White, Gabriel Magalhaes and Thomas Partey could all come into the line-up.
Arsenal predicted starting XI:
Ramsdale;
Cedric, White, Gabriel, Tavares;
Xhaka, Partey;
Saka, Odegaard, Martinelli;
Jesus