Manchester City lost Nathan Ake to an apparent hamstring issue with 54 minutes gone against Leeds, and the Dutchman has been ruled out of the first leg.
Cole Palmer‘s ankle is also giving him grief, but the 21-year-old has been named in the travelling party.
With Ake sidelined, Guardiola will be tempted to recall Kyle Walker to try to keep Vinicius Junior at bay, while a host of well-rested regulars in Rodri, John Stones,
Bernardo Silva and Jack Grealish are also primed to return to the first XI after Guardiola rang the changes at the weekend.
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In more positive news, Kevin De Bruyne returned from fitness to start against Leeds after missing the previous two games.
Ilkay Gundogan and Riyad Mahrez, though, were the stars of the show, with two goals and two assists between them, and will be hoping to start the titantic Santiago Bernabeu clash.
Man City full squad:
Ederson, Ortega, Carson;
Walker, Ruben Dias, Stones, Ake, Laporte, Gomez, Akanji, Lewis;
Phillips, Gundogan, Grealish, Rodri, De Bruyne, Bernardo, Mahrez, Perrone, Foden, Palmer;
Haaland, Alvarez
Manchester City Possible XI:
Ederson;
Walker, Dias, Akanji; Stones, Rodri;
Silva, De Bruyne, Gundogan, Grealish;
Haaland
