Manchester United are without Christian Eriksen until April with an ankle injury, while Donny van de Beek and Scott McTominay are also ruled out with respective knee and muscle problems.
David de Gea and Marcus Rashford are both expected to return to the starting lineup after beginning on the substitutes’ bench in midweek, with Tom Heaton and Alejandro Garnacho set to make way.
Jadon Sancho, who recently made his return to action is also in line to feaure in at least some capacity.
Midfielder Sabitzer missed the midweek win over Nottingham Forest while waiting for his visa and the club have confirmed they
are still waiting on his paperwork to be completed ahead of welcoming Palace to Old Trafford.
Fred will likely line-up alongside Casemiro with the absent of Christian Eriksen.
Read Also: Saturday’s Transfer Gossip: Mudryk, Sabitzer, Aubameyang, Becker, Antonio, Osimhen, Saka, Mount, Garnacho
A key decision for United comes in attack is the return of Anthony Martial and Sancho after their substitute appearances against Forest marked returns from long spells out.
Predicted Manchester United XI:
Wan-Bissaka, Varane, Martinez, Shaw;
Antony, Fernandes, Rashford;