Manchester United will be seeking revenge when they host Manchester City after suffering a humbling 6-3 defeat at the Etihad Stadium in October.
Man United right-back Diogo Dalot is “not available” for Saturday’s derby due to a hamstring problem, while Donny van de Beek has been ruled out for the rest of the season with a serious knee injury.
Axel Tuanzebe is also sidelined through injury.
Meanwhile United are not expected to give incoming new signing Wout Weghorst his debut against Manchester City.
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Lisandro Martinez is ready for his first Premier League start since the World Cup,
partnering Raphael Varane at centre-back, meaning Luke Shaw can take his place at left-back after a stint in the middle.
Bruno Fernandes is available again after suspension and will support Martial alongside Antony and the in-form Marcus Rashford.
Manchester City: The visitor will be without John Stones as they prepare to face Manchester United in the derby.
Manuel Akanji will come into the side to partner Aymeric Laporte, which will allow Kyle Walker to return at right-back.
Joao Cancelo has had a torrid time of last and will likely again be dropped.
Kalvin Phillips and Sergio Gomez will also drop out, as the likes of Kevin De Bruyne, Rodri and Bernardo Silva come in.
Erling Haaland will also return, likely supported by two of Phil Foden, Riyad Mahrez and Jack Grealish, as he looks to add to the hat-trick he scored in the reverse fixture earlier this season.
Manchester United Possible Lineup:
De Gea;
Wan-Bissaka, Varane, Martinez, Shaw;
Casemiro, Eriksen;
Antony, Fernandes, Rashford;
Martial
Manchester City Possible Lineup:
Ederson;
Walker, Laporte, Akanji, Ake;
De Bruyne, Rodri, Bernardo;
Mahrez, Haaland, Grealish
