Liverpool will encounter Sparta Prague in the last-16 stage, with West Ham facing Freiburg and Brighton meeting Roma.
The Premier League leaders will journey to the Czech capital for the initial leg on March 7, followed by a return fixture at Anfield a week later, in a tournament Liverpool has previously clinched three times.
Brighton embarks on their first European journey to Rome after topping Group B, which included Marseille, Ajax, and AEK Athens.
Arguably, their matchup is the most captivating of the round.
Defending Europa Conference League champions West Ham confront German side Freiburg, while Rangers contend with two-time European champions Benfica from Portugal.
EUROPA LEAGUE LAST-16 DRAW IN FULL
Qarabag vs Bayer Leverkusen
AC Milan vs Slavia Prague
Sporting vs Atalanta
Freiburg vs West Ham
Benfica vs Rangers
Roma vs Brighton
Marseille vs Villarreal
Sparta Prague vs Liverpool
When will the Europa League last 16 games be played?
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The unseeded sides will host the first legs of the round on March 7, with the seeded teams at home for the return fixtures a week later on March 14.
The draws for the quarter-final and semi-final will then be held on March 15.
This year’s final will be held in Dublin, Ireland on May 22.
EUROPA CONFERENCE LEAGUE Last-16 Draw
Servette vs Viktoria Plzen
Ajax vs Aston Villa
Molde vs Club Brugge
Union Saint-Gilloise vs Fenerbahce
Dinamo Zagreb vs PAOK
Sturm Graz vs Lille
Maccabi Haifa vs Fiorentina
Olympiakos vs Maccabi Tel Aviv
